Jobs & Economy in Cape Girardeau

Cape Girardeau's economy runs on a genuinely diversified base anchored substantially by regional healthcare and higher education.

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A real, substantial regional healthcare hub

Saint Francis Healthcare System's 306-bed Medical Center and SoutheastHEALTH together anchor Cape Girardeau's real role as the healthcare hub for 22 counties and 250,000+ southeast Missouri/southern Illinois residents.

Southeast Missouri State University's real presence

Southeast Missouri State University employs approximately 1,120 full-time workers and recently broke ground on the 55,000-square-foot Roy Blunt Health Professions Hall, a real, current facility investment.

A genuinely stable regional labor market

Cape Girardeau's unemployment rate ran approximately 3% as of this pass, typically running below both the U.S. and Missouri state averages.

Key takeaways

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Last reviewed: 2026-08-27. Independent research; not financial, tax, or legal advice -- confirm current figures with a local professional before making a decision.